CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation

CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation

Abstract Aims CircRNAs could regulate macrophage pyroptosis, which has the potential in promoting the synergistic effect of inflammation and matrix metalloproteinase (MMP) activity in abdominal aortic aneurysm (AAA). But the roles of circRNAs in modulating macrophage pyroptosis in the AAA remain unk...

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Bibliographic Details
Main Authors: Donghua Cai, Chuling Li, Yingyuan Zhang, Sisi He, Yihai Guo, Wangjun Liao, Yulin Liao, Jianping Bin, Xiang He
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Clinical and Translational Medicine
Subjects:
abdominal aortic aneurysm
circHipk3
macrophage
NLRP3
pyroptosis
Online Access:https://doi.org/10.1002/ctm2.70102
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