Origin and interpretation of cancer transcriptome profiling: the essential role of the stroma in determining prognosis and drug resistance

Abstract Mesenchymal gene expression in tumors has been implicated in cancer recurrence, metastasis, and poor prognosis of patients. The source of these mesenchymal signals has been mostly attributed to the epithelial‐to‐mesenchymal transition‐like phenotype of epithelial tumor cells. However, recen...

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Bibliographic Details
Main Authors: Nicolas Goossens, Yujin Hoshida, Julio A Aguirre‐Ghiso
Format: Article
Language:English
Published: Springer Nature 2015-08-01
Series:EMBO Molecular Medicine
Online Access:https://doi.org/10.15252/emmm.201505284
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