Treatment approaches in advanced penile cancer: targeted therapies and immunotherapy
Penile cancer is a rare genitourinary malignancy which can be treated with surgery or radiation for localized disease, but often requires systemic treatment with chemotherapy for recurrent or metastatic disease. With the emergence of immune checkpoint inhibitors and targeted therapies for specific g...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1457006/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841527920912236544 |
|---|---|
| author | David J. Benjamin Robert C. Hsu |
| author_facet | David J. Benjamin Robert C. Hsu |
| author_sort | David J. Benjamin |
| collection | DOAJ |
| description | Penile cancer is a rare genitourinary malignancy which can be treated with surgery or radiation for localized disease, but often requires systemic treatment with chemotherapy for recurrent or metastatic disease. With the emergence of immune checkpoint inhibitors and targeted therapies for specific genomic aberrations in the treatment of over a dozen other cancers, recent studies have sought to identify therapies other than chemotherapy in treating this uncommon cancer. Several ongoing trials involving immune checkpoint inhibitors, tyrosine kinase inhibitors, and antibody drug conjugates are attempting to identify additional therapies. |
| format | Article |
| id | doaj-art-acd174a198fb4d378544812173647bd4 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-acd174a198fb4d378544812173647bd42025-01-15T05:10:27ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14570061457006Treatment approaches in advanced penile cancer: targeted therapies and immunotherapyDavid J. Benjamin0Robert C. Hsu1Department of Medical Oncology, Hoag Family Cancer Institute, Newport Beach, CA, United StatesDepartment of Internal Medicine, Division of Medical Oncology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United StatesPenile cancer is a rare genitourinary malignancy which can be treated with surgery or radiation for localized disease, but often requires systemic treatment with chemotherapy for recurrent or metastatic disease. With the emergence of immune checkpoint inhibitors and targeted therapies for specific genomic aberrations in the treatment of over a dozen other cancers, recent studies have sought to identify therapies other than chemotherapy in treating this uncommon cancer. Several ongoing trials involving immune checkpoint inhibitors, tyrosine kinase inhibitors, and antibody drug conjugates are attempting to identify additional therapies.https://www.frontiersin.org/articles/10.3389/fonc.2024.1457006/fullpenile cancertargeted therapyimmune checkpoint inhibitorantibody drug conjugatevaccine |
| spellingShingle | David J. Benjamin Robert C. Hsu Treatment approaches in advanced penile cancer: targeted therapies and immunotherapy Frontiers in Oncology penile cancer targeted therapy immune checkpoint inhibitor antibody drug conjugate vaccine |
| title | Treatment approaches in advanced penile cancer: targeted therapies and immunotherapy |
| title_full | Treatment approaches in advanced penile cancer: targeted therapies and immunotherapy |
| title_fullStr | Treatment approaches in advanced penile cancer: targeted therapies and immunotherapy |
| title_full_unstemmed | Treatment approaches in advanced penile cancer: targeted therapies and immunotherapy |
| title_short | Treatment approaches in advanced penile cancer: targeted therapies and immunotherapy |
| title_sort | treatment approaches in advanced penile cancer targeted therapies and immunotherapy |
| topic | penile cancer targeted therapy immune checkpoint inhibitor antibody drug conjugate vaccine |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1457006/full |
| work_keys_str_mv | AT davidjbenjamin treatmentapproachesinadvancedpenilecancertargetedtherapiesandimmunotherapy AT robertchsu treatmentapproachesinadvancedpenilecancertargetedtherapiesandimmunotherapy |