The Thyroid Hormone Analog GC‐1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization

The Thyroid Hormone Analog GC‐1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization

Abstract Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a life‐threatening condition with a high mortality rate of ≈40%. Thyroid hormones (THs) play crucial roles in maintaining homeostasis of the cellular microenvironment under stress. The previous studies confirmed that the...

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Bibliographic Details
Main Authors: Bin Li, Cong Xia, Wanyu He, Jingyi Liu, Ruoyu Duan, Zhihua Ji, Xiaoyue Pan, Yanlin Zhou, Guoying Yu, Lan Wang
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
ALI/ARDS
DNMT3b‐PPARγ‐NF‐κB pathway
GC‐1
macrophage polarization
thyroid hormone
Online Access:https://doi.org/10.1002/advs.202401931
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https://doi.org/10.1002/advs.202401931

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