Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB

Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB

Abstract Background Microglia play crucial roles in maintaining neuronal homeostasis but have been implicated in contributing to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, the role of microglia in ALS/FTD remains incompletely understood. Methods Here, we generate...

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Main Authors: Benjamin E. Clarke, Oliver J. Ziff, Giulia Tyzack, Marija Petrić Howe, Yiran Wang, Pierre Klein, Claudia A. Smith, Cameron A. Hall, Adel Helmy, Michael Howell, Gavin Kelly, Rickie Patani
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Neurodegeneration
Online Access:https://doi.org/10.1186/s13024-024-00773-1
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https://doi.org/10.1186/s13024-024-00773-1

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