SURVIVAL OF LIVER CELLS, IMMOBILIZED ON 3D-MATRIXES, IN LIVER FAILURE MODEL

SURVIVAL OF LIVER CELLS, IMMOBILIZED ON 3D-MATRIXES, IN LIVER FAILURE MODEL

It was examined a new method for correction of hepatic failure by transplantation of liver support biounit (liver cells, immobilized on biocompatible and biodegradable 3D-matrixes ElastoPOB®) into small intestine mesentery. It was determined that after modeling of acute hepatic failure on dogs by 65...

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Main Authors: M. Y. Shagidulin, N. A. Onishchenko, M. E. Krasheninnikov, I. M. Iljinsky, N. P. Mogeiko, N. P. Shmerko, A. A. Andriyanova, P. V. Avramov, E. A. Nemets, V. I. Sevastjanov, S. V. Gautier
Format: Article
Language:Russian
Published: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov 2011-06-01
Series:Вестник трансплантологии и искусственных органов
Subjects:
hepatic failure
immobilized hepatocytes
liver support unit.
Online Access:https://journal.transpl.ru/vtio/article/view/417
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Summary:It was examined a new method for correction of hepatic failure by transplantation of liver support biounit (liver cells, immobilized on biocompatible and biodegradable 3D-matrixes ElastoPOB®) into small intestine mesentery. It was determined that after modeling of acute hepatic failure on dogs by 65–70% liver resection) and transplantation liver support biounit the restoration of disturbed biochemical indecies (such as total protein, lactate, cytolytic ensymes-ALT, AST, ALP, LDH, fibrinogen, protrombine index and others) took place more rapidly on 9–14th day instead of 18th day in control. It was made a preposition about efficiency of the suggested method for correction both acute hepatic failure because even 90 days after transplantation of liver support biounit alive hepatocytes and neogenic plethoric vessels, growing through matrix were revealed.
ISSN:1995-1191

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