Pregabalin produces analgesia in males but not females in an animal model of chronic widespread muscle pain

Abstract. Introduction:. Pregabalin, which acts on the α2δ-1 subunit of voltage-gated calcium channels, relieves ≥50% of pain in a third of individuals with fibromyalgia. Thus far, preclinical studies of pregabalin have predominantly used male animals. Objectives:. The purpose of our study was to i...

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Bibliographic Details
Main Authors: Ashley N. Plumb, Kazuhiro Hayashi, Adam Janowski, Angela Smith, Lynn Rasmussen, Kathleen A. Sluka, Joseph B. Lesnak
Format: Article
Language:English
Published: Wolters Kluwer 2024-12-01
Series:PAIN Reports
Online Access:http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000001207
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