The prognostic role of ACSL4 in postoperative adjuvant TACE-treated HCC: implications for therapeutic response and mechanistic insights

The prognostic role of ACSL4 in postoperative adjuvant TACE-treated HCC: implications for therapeutic response and mechanistic insights

Abstract Background The response of hepatocellular carcinoma (HCC) to transarterial chemoembolization (TACE) treatment and its underlying mechanisms remain elusive. This study investigates the role of enzymes involved in fatty acid activation, specifically Acyl-CoA synthetase long chain 4 (ACSL4), i...

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Main Authors: Ji Feng, Jin-Lian Bin, Xi-Wen Liao, Yong Wu, Yue Tang, Pei-Zhi Lu, Guang-Zhi Zhu, Qian-Ru Cui, Yock Young Dan, Guo-Huan Yang, Li-Xin Li, Jing-Huan Deng, Tao Peng, Shing Chuan Hooi, Jing Zhou, Guo-Dong Lu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HCC
TACE
ACSL4
Glucose starvation
Canagliflozin
Online Access:https://doi.org/10.1186/s13046-024-03222-5
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https://doi.org/10.1186/s13046-024-03222-5

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