Assessing the Effects of HbA1c Reduction on Alleviating Chronic Nonspecific Low Back Pain in Prediabetic Non-obese Patients: A Non-Randomized Controlled Trial
Background: Pre-diabetes, characterized by elevated glycemic indices, poses a high risk of diabetes development, and is increasingly linked to non-specific low back pain. While mechanisms remain incompletely understood, metabolic, inflammatory, and neurological factors are implicated. Dietary interv...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-11-01
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| Series: | Clinical Medicine Insights: Endocrinology and Diabetes |
| Online Access: | https://doi.org/10.1177/11795514241300995 |
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| author | Ghazwan Abdulla Hasan Ahmed Dheyaa Al-Obaidi Hashim Talib Hashim Mustafa Najah Al-Obaidi Yousif Ali Al-Saady Assalah Othman Sara S. Khunda Omar Saab Hasan Al-Obaidi Nooraldin Merza |
| author_facet | Ghazwan Abdulla Hasan Ahmed Dheyaa Al-Obaidi Hashim Talib Hashim Mustafa Najah Al-Obaidi Yousif Ali Al-Saady Assalah Othman Sara S. Khunda Omar Saab Hasan Al-Obaidi Nooraldin Merza |
| author_sort | Ghazwan Abdulla Hasan |
| collection | DOAJ |
| description | Background: Pre-diabetes, characterized by elevated glycemic indices, poses a high risk of diabetes development, and is increasingly linked to non-specific low back pain. While mechanisms remain incompletely understood, metabolic, inflammatory, and neurological factors are implicated. Dietary interventions, including low-glycemic and anti-inflammatory diets, alongside weight management, may improve outcomes in this population. Objectives: In this non-randomized controlled trial, we aim to evaluate the influence of decreasing HbA1c levels on reducing chronic non-specific low back pain in pre-diabetic, non-obese individuals, as well as emphasizing the importance of such a study in supporting the literature. Methods: A non-randomized controlled single-blind clinical trial was conducted among 82 participants with chronic non-specific low back pain and pre-diabetes at an outpatient clinic in Baghdad from the 30th of January to the 22nd of September. The intervention methods aimed at reducing HbA1c levels to assess the reduction impact on alleviating chronic non-specific low back pain included dietary adjustments, sleep optimization, and correction of vitamins and minerals deficiencies. The follow-up process was conducted individually for each participant, with a monthly assessment over a period of six months. Results: At 12 weeks a significant decrease in chronic non-specific low back pain severity was observed in patients with lower HbA1C levels yielding a P -value of .021. Similarly, at 24 weeks there was a decline in the number of patients who reported chronic non-specific low back pain, and the association to lower HbA1C levels was significant with a p -value of .005. Conclusion: This study suggests the presence of a statistically significant association between reduction of HbA1C levels and ensuing improvement in chronic non-specific low back pain symptoms in non-obese prediabetic patients. |
| format | Article |
| id | doaj-art-ac46c64eb4ba4e44aabef51aeb1f46f9 |
| institution | Kabale University |
| issn | 1179-5514 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Endocrinology and Diabetes |
| spelling | doaj-art-ac46c64eb4ba4e44aabef51aeb1f46f92024-11-18T07:03:19ZengSAGE PublishingClinical Medicine Insights: Endocrinology and Diabetes1179-55142024-11-011710.1177/11795514241300995Assessing the Effects of HbA1c Reduction on Alleviating Chronic Nonspecific Low Back Pain in Prediabetic Non-obese Patients: A Non-Randomized Controlled TrialGhazwan Abdulla Hasan0Ahmed Dheyaa Al-Obaidi1Hashim Talib Hashim2Mustafa Najah Al-Obaidi3Yousif Ali Al-Saady4Assalah Othman5Sara S. Khunda6Omar Saab7Hasan Al-Obaidi8Nooraldin Merza9Middle East Private Hospital, Baghdad, IraqCollege of Medicine, University of Baghdad, Baghdad, IraqCollege of Medicine, University of Warith Al-Anbiyaa, Karbala, IraqCollege of Medicine, University of Baghdad, Baghdad, IraqCollege of Medicine, University of Baghdad, Baghdad, IraqD’Youville University School of Pharmacy, Buffalo, New York, USAMedical City Complex, Baghdad, IraqDepartment of Internal Medicine, Cleavland Clinic, Cleavland, OH, USAJamaica Hospital Medical Center, New York City, USADepartment of Internal Medicine, University of Toledo, Toledo, OH, USABackground: Pre-diabetes, characterized by elevated glycemic indices, poses a high risk of diabetes development, and is increasingly linked to non-specific low back pain. While mechanisms remain incompletely understood, metabolic, inflammatory, and neurological factors are implicated. Dietary interventions, including low-glycemic and anti-inflammatory diets, alongside weight management, may improve outcomes in this population. Objectives: In this non-randomized controlled trial, we aim to evaluate the influence of decreasing HbA1c levels on reducing chronic non-specific low back pain in pre-diabetic, non-obese individuals, as well as emphasizing the importance of such a study in supporting the literature. Methods: A non-randomized controlled single-blind clinical trial was conducted among 82 participants with chronic non-specific low back pain and pre-diabetes at an outpatient clinic in Baghdad from the 30th of January to the 22nd of September. The intervention methods aimed at reducing HbA1c levels to assess the reduction impact on alleviating chronic non-specific low back pain included dietary adjustments, sleep optimization, and correction of vitamins and minerals deficiencies. The follow-up process was conducted individually for each participant, with a monthly assessment over a period of six months. Results: At 12 weeks a significant decrease in chronic non-specific low back pain severity was observed in patients with lower HbA1C levels yielding a P -value of .021. Similarly, at 24 weeks there was a decline in the number of patients who reported chronic non-specific low back pain, and the association to lower HbA1C levels was significant with a p -value of .005. Conclusion: This study suggests the presence of a statistically significant association between reduction of HbA1C levels and ensuing improvement in chronic non-specific low back pain symptoms in non-obese prediabetic patients.https://doi.org/10.1177/11795514241300995 |
| spellingShingle | Ghazwan Abdulla Hasan Ahmed Dheyaa Al-Obaidi Hashim Talib Hashim Mustafa Najah Al-Obaidi Yousif Ali Al-Saady Assalah Othman Sara S. Khunda Omar Saab Hasan Al-Obaidi Nooraldin Merza Assessing the Effects of HbA1c Reduction on Alleviating Chronic Nonspecific Low Back Pain in Prediabetic Non-obese Patients: A Non-Randomized Controlled Trial Clinical Medicine Insights: Endocrinology and Diabetes |
| title | Assessing the Effects of HbA1c Reduction on Alleviating Chronic Nonspecific Low Back Pain in Prediabetic Non-obese Patients: A Non-Randomized Controlled Trial |
| title_full | Assessing the Effects of HbA1c Reduction on Alleviating Chronic Nonspecific Low Back Pain in Prediabetic Non-obese Patients: A Non-Randomized Controlled Trial |
| title_fullStr | Assessing the Effects of HbA1c Reduction on Alleviating Chronic Nonspecific Low Back Pain in Prediabetic Non-obese Patients: A Non-Randomized Controlled Trial |
| title_full_unstemmed | Assessing the Effects of HbA1c Reduction on Alleviating Chronic Nonspecific Low Back Pain in Prediabetic Non-obese Patients: A Non-Randomized Controlled Trial |
| title_short | Assessing the Effects of HbA1c Reduction on Alleviating Chronic Nonspecific Low Back Pain in Prediabetic Non-obese Patients: A Non-Randomized Controlled Trial |
| title_sort | assessing the effects of hba1c reduction on alleviating chronic nonspecific low back pain in prediabetic non obese patients a non randomized controlled trial |
| url | https://doi.org/10.1177/11795514241300995 |
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