Fate and propagation of endogenously formed Tau aggregates in neuronal cells

Fate and propagation of endogenously formed Tau aggregates in neuronal cells

Abstract Tau accumulation in the form of neurofibrillary tangles in the brain is a hallmark of tauopathies such as Alzheimer's disease (AD). Tau aggregates accumulate in brain regions in a defined spatiotemporal pattern and may induce the aggregation of native Tau in a prion‐like manner. Howeve...

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Bibliographic Details
Main Authors: Patricia Chastagner, Frida Loria, Jessica Y Vargas, Josh Tois, Marc I Diamond, George Okafo, Christel Brou, Chiara Zurzolo
Format: Article
Language:English
Published: Springer Nature 2020-11-01
Series:EMBO Molecular Medicine
Subjects:
autophagy
Intercellular spreading
prion‐like seeding
Tau aggregates
tunneling nanotubes
Online Access:https://doi.org/10.15252/emmm.202012025
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https://doi.org/10.15252/emmm.202012025

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