Revealing a novel Decorin-expressing tumor stromal subset in hepatocellular carcinoma via integrative analysis single-cell RNA sequencing

Revealing a novel Decorin-expressing tumor stromal subset in hepatocellular carcinoma via integrative analysis single-cell RNA sequencing

Abstract Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, emphasizing the need for novel therapeutic strategies. Decorin (DCN), a chondroitin sulfate proteoglycan (CSPG), has been proposed as a tumor suppressor, yet its precise role in HCC and the tumor microenviro...

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Bibliographic Details
Main Authors: Chi Hsiao, Wen-Chieh Liao, Ju-Pi Li, Yu-Cheng Chou, Yu-Lun Chou, Jeng-Rong Lin, Chia-Hua Chen, Chiung-Hui Liu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cancer Cell International
Subjects:
Hepatocellular carcinoma
Tumor microenvironment
Chondroitin polymerizing factor
Chondroitin sulfate
Decorin
Online Access:https://doi.org/10.1186/s12935-025-03811-0
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https://doi.org/10.1186/s12935-025-03811-0

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