EnGCI: enhancing GPCR-compound interaction prediction via large molecular models and KAN network

Abstract Background Identifying GPCR-compound interactions (GCI) plays a significant role in drug discovery and chemogenomics. Machine learning, particularly deep learning, has become increasingly influential in this domain. Large molecular models, due to their ability to capture detailed structural...

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Bibliographic Details
Main Authors: Weihao Liu, Xiaoli Li, Bo Hang, Pu Wang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Biology
Subjects:
Online Access:https://doi.org/10.1186/s12915-025-02238-3
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