Integrated analysis identifies P4HA2 as a key regulator of STAT1-mediated colorectal cancer progression and a potential biomarker for precision therapy

Integrated analysis identifies P4HA2 as a key regulator of STAT1-mediated colorectal cancer progression and a potential biomarker for precision therapy

IntroductionP4HA2 is implicated in regulating tumor microenvironment formation and may play roles in inflammation and tumor immunity. However, its mechanistic involvement in colorectal cancer (CRC) remains largely unexplored.MethodsWe analyzed P4HA2 expression in CRC tissues and correlated it with c...

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Bibliographic Details
Main Authors: Qianshi Zhang, Yinan Zhang, Zhiwei Sun, Huanle Wang, Guohang Dai, Yue Meng, Shasha Shi, Shuangyi Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
P4HA2
colorectal cancer
STAT1
prognostic marker
PD-L1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1581860/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1581860/full

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