Role of CXCL10 released from osteocytes in response to TNF-α stimulation on osteoclasts

Role of CXCL10 released from osteocytes in response to TNF-α stimulation on osteoclasts

Abstract Tumor necrosis factor-alpha (TNF-α) is a significant cytokine that regulates bone resorption under inflammatory conditions. However, its mechanism of action in osteocytes remains unclear. In this study, highly purified osteocytes were isolated from dentin matrix protein 1 (DMP1)-Topaz mice...

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Main Authors: Mariko Miura, Hideki Kitaura, Fumitoshi Ohori, Kohei Narita, Jiayi Ren, Takahiro Noguchi, Aseel Marahleh, Jinghan Ma, Angyi Lin, Ziqiu Fan, Itaru Mizoguchi
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Osteocyte
Osteoclast
TNF-α
CXCL10
Bone resorption
Migration
Online Access:https://doi.org/10.1038/s41598-025-87092-7
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