Design and synthesis of thiazole-based hydroxamate histone deacetylase inhibitors with potent antitumor efficacy by inducing apoptosis, pyroptosis and cell cycle arrest

Design and synthesis of thiazole-based hydroxamate histone deacetylase inhibitors with potent antitumor efficacy by inducing apoptosis, pyroptosis and cell cycle arrest

Abstract The dysfunction of HDACs is closely related to tumorigenesis and development, which has emerged as an attractive target for cancer therapy. In this study, a series of thiazole-containing hydroxamate derivatives were designed and synthesized as novel HDAC inhibitors. Among these inhibitors,...

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Bibliographic Details
Main Authors: Zhijian Li, Huiran Qiu, Wenxia Lu, Namin Duan, Shule Fan, Rui Zhou, Xiangzhi Li, Hua Zhang, Ning Liu, Feifei Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Histone deacetylase inhibitor
Thiazole
Hydroxamate
Anticancer
Online Access:https://doi.org/10.1038/s41598-025-08474-5
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https://doi.org/10.1038/s41598-025-08474-5

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