Optimization of the supercritical extraction and decarboxylation process of industrial hemp
Cannabinoids are the main active ingredients of Cannabis sativa L., obtained by a suitable extraction method and decarboxylation, in which the acid forms of the cannabinoids are converted into active forms. Supercritical CO2 extraction method and decarboxylation process were optimized for 7 cannabin...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of CO2 Utilization |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212982024003421 |
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| author | Taja Žitek Makoter Petra Kotnik Teo Makoter Željko Knez Maša Knez Marevci |
| author_facet | Taja Žitek Makoter Petra Kotnik Teo Makoter Željko Knez Maša Knez Marevci |
| author_sort | Taja Žitek Makoter |
| collection | DOAJ |
| description | Cannabinoids are the main active ingredients of Cannabis sativa L., obtained by a suitable extraction method and decarboxylation, in which the acid forms of the cannabinoids are converted into active forms. Supercritical CO2 extraction method and decarboxylation process were optimized for 7 cannabinoids (CBD, CBDA, THC, THCA, CBGA, CBN and CBC). The optimal extraction conditions for all cannabinoids were determined at a temperature of 60 °C and a pressure of 300 bar to 550 bar. At higher temperatures and reaction times, a significant depletion of neutral cannabinoids was observed. The optimal conditions of the decarboxylation process varied depending on the component. For the CBD component, which could be measured in the highest concentrations (560 mg/g), the optimal conditions were 140 °C and 10 min. The study can be an important model for predicting the behavior of cannabinoids under certain parameters. |
| format | Article |
| id | doaj-art-ab052d0f01914dc48174fca120c65966 |
| institution | Kabale University |
| issn | 2212-9839 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of CO2 Utilization |
| spelling | doaj-art-ab052d0f01914dc48174fca120c659662025-01-13T04:18:51ZengElsevierJournal of CO2 Utilization2212-98392025-01-0191103007Optimization of the supercritical extraction and decarboxylation process of industrial hempTaja Žitek Makoter0Petra Kotnik1Teo Makoter2Željko Knez3Maša Knez Marevci4Laboratory of separation process and product design, Faculty of Chemistry and Chemical Engeneering, University of Maribor, Slovenia; Laboratory of Chemistry, Faculty of Medicine, University of Maribor, SloveniaLaboratory of separation process and product design, Faculty of Chemistry and Chemical Engeneering, University of Maribor, Slovenia; Laboratory of Chemistry, Faculty of Medicine, University of Maribor, SloveniaLaboratory of Thermoenergetics, Faculty of Chemistry and Chemical Engeneering, University of Maribor, SloveniaLaboratory of separation process and product design, Faculty of Chemistry and Chemical Engeneering, University of Maribor, Slovenia; Laboratory of Chemistry, Faculty of Medicine, University of Maribor, SloveniaLaboratory of separation process and product design, Faculty of Chemistry and Chemical Engeneering, University of Maribor, Slovenia; Corresponding author.Cannabinoids are the main active ingredients of Cannabis sativa L., obtained by a suitable extraction method and decarboxylation, in which the acid forms of the cannabinoids are converted into active forms. Supercritical CO2 extraction method and decarboxylation process were optimized for 7 cannabinoids (CBD, CBDA, THC, THCA, CBGA, CBN and CBC). The optimal extraction conditions for all cannabinoids were determined at a temperature of 60 °C and a pressure of 300 bar to 550 bar. At higher temperatures and reaction times, a significant depletion of neutral cannabinoids was observed. The optimal conditions of the decarboxylation process varied depending on the component. For the CBD component, which could be measured in the highest concentrations (560 mg/g), the optimal conditions were 140 °C and 10 min. The study can be an important model for predicting the behavior of cannabinoids under certain parameters.http://www.sciencedirect.com/science/article/pii/S2212982024003421ExtractionSupercritical fluidsCannabinoidsDecarboxylationCannabis sativa L |
| spellingShingle | Taja Žitek Makoter Petra Kotnik Teo Makoter Željko Knez Maša Knez Marevci Optimization of the supercritical extraction and decarboxylation process of industrial hemp Journal of CO2 Utilization Extraction Supercritical fluids Cannabinoids Decarboxylation Cannabis sativa L |
| title | Optimization of the supercritical extraction and decarboxylation process of industrial hemp |
| title_full | Optimization of the supercritical extraction and decarboxylation process of industrial hemp |
| title_fullStr | Optimization of the supercritical extraction and decarboxylation process of industrial hemp |
| title_full_unstemmed | Optimization of the supercritical extraction and decarboxylation process of industrial hemp |
| title_short | Optimization of the supercritical extraction and decarboxylation process of industrial hemp |
| title_sort | optimization of the supercritical extraction and decarboxylation process of industrial hemp |
| topic | Extraction Supercritical fluids Cannabinoids Decarboxylation Cannabis sativa L |
| url | http://www.sciencedirect.com/science/article/pii/S2212982024003421 |
| work_keys_str_mv | AT tajazitekmakoter optimizationofthesupercriticalextractionanddecarboxylationprocessofindustrialhemp AT petrakotnik optimizationofthesupercriticalextractionanddecarboxylationprocessofindustrialhemp AT teomakoter optimizationofthesupercriticalextractionanddecarboxylationprocessofindustrialhemp AT zeljkoknez optimizationofthesupercriticalextractionanddecarboxylationprocessofindustrialhemp AT masaknezmarevci optimizationofthesupercriticalextractionanddecarboxylationprocessofindustrialhemp |