Protective effects of vitamin e in experimentally induced rhabdomyolysis
<b>Aim:</b> Evaluation of the protective effects of vitamin E administration in a rat model of rhabdomyolysis.<p> <b>Material and Method:</b> Twenty one rats were divided to three equal groups; control (Group 1), glycerol (50% glycerol, 7 mL/kg, IM) and glycerol (50% gl...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1011 |
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| author | Javad Tajik Reza Kheirandish Hamideh Rohani Shima Abbasi |
| author_facet | Javad Tajik Reza Kheirandish Hamideh Rohani Shima Abbasi |
| author_sort | Javad Tajik |
| collection | DOAJ |
| description | <b>Aim:</b> Evaluation of the protective effects of vitamin E administration
in a rat model of rhabdomyolysis.<p>
<b>Material and Method:</b> Twenty one rats were divided to
three equal groups; control (Group 1), glycerol (50% glycerol,
7 mL/kg, IM) and glycerol (50% glycerol, 7 mL/kg, IM) +
Vitamin E (100 mg/kg, IP, SID). Ninety-six hours after glycerol
injection, blood samples were collected. Serum creatinine,
blood urea nitrogen, creatine kinase, aspartate aminotransferase,
alanine aminotransferase and lactate dehydrogenase
levels were measured. Histopathologic pattern of hepatic
and renal tissue damages was also evaluated.<p>
<b>Results:</b> Glycerol + vitamin E groups had lower (P<0.05)
creatinine, lactate dehydrogenase and creatine kinase levels
than the glycerol group, and the administration of vitamin E
caused lesser renal tubular damages in glycerol + vitamin E
group rather than in glycerol group.<p>
<b>Conclusions:</b> Vitamin E administration may decrease the
muscle injury and renal damage in rhabdomyolysis cases. |
| format | Article |
| id | doaj-art-aad0211fdb354d97ba52c6d2f8d1fa04 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-aad0211fdb354d97ba52c6d2f8d1fa042025-01-02T22:36:24ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532941801841011Protective effects of vitamin e in experimentally induced rhabdomyolysisJavad Tajik0Reza Kheirandish1Hamideh Rohani2Shima Abbasi3Department of Clinical Studies, Shahid Bahonar University of Kerman, Kerman, IranDepartment of Pathobiology, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, IranDepartment of Clinical Studies, Shahid Bahonar University of Kerman, Kerman, IranDepartment of Clinical Studies, Shahid Bahonar University of Kerman, Kerman, Iran<b>Aim:</b> Evaluation of the protective effects of vitamin E administration in a rat model of rhabdomyolysis.<p> <b>Material and Method:</b> Twenty one rats were divided to three equal groups; control (Group 1), glycerol (50% glycerol, 7 mL/kg, IM) and glycerol (50% glycerol, 7 mL/kg, IM) + Vitamin E (100 mg/kg, IP, SID). Ninety-six hours after glycerol injection, blood samples were collected. Serum creatinine, blood urea nitrogen, creatine kinase, aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase levels were measured. Histopathologic pattern of hepatic and renal tissue damages was also evaluated.<p> <b>Results:</b> Glycerol + vitamin E groups had lower (P<0.05) creatinine, lactate dehydrogenase and creatine kinase levels than the glycerol group, and the administration of vitamin E caused lesser renal tubular damages in glycerol + vitamin E group rather than in glycerol group.<p> <b>Conclusions:</b> Vitamin E administration may decrease the muscle injury and renal damage in rhabdomyolysis cases.http://eurasianjvetsci.org/pdf.php3?id=1011vitamin erenal damagesrhabdomyolysis |
| spellingShingle | Javad Tajik Reza Kheirandish Hamideh Rohani Shima Abbasi Protective effects of vitamin e in experimentally induced rhabdomyolysis Eurasian Journal of Veterinary Sciences vitamin e renal damages rhabdomyolysis |
| title | Protective effects of vitamin e in experimentally induced rhabdomyolysis |
| title_full | Protective effects of vitamin e in experimentally induced rhabdomyolysis |
| title_fullStr | Protective effects of vitamin e in experimentally induced rhabdomyolysis |
| title_full_unstemmed | Protective effects of vitamin e in experimentally induced rhabdomyolysis |
| title_short | Protective effects of vitamin e in experimentally induced rhabdomyolysis |
| title_sort | protective effects of vitamin e in experimentally induced rhabdomyolysis |
| topic | vitamin e renal damages rhabdomyolysis |
| url | http://eurasianjvetsci.org/pdf.php3?id=1011 |
| work_keys_str_mv | AT javadtajik protectiveeffectsofvitamineinexperimentallyinducedrhabdomyolysis AT rezakheirandish protectiveeffectsofvitamineinexperimentallyinducedrhabdomyolysis AT hamidehrohani protectiveeffectsofvitamineinexperimentallyinducedrhabdomyolysis AT shimaabbasi protectiveeffectsofvitamineinexperimentallyinducedrhabdomyolysis |