Challenges in Diagnosing Focal Liver Lesions Using Contrast-Enhanced Ultrasound
<b>Background:</b> Contrast-enhanced ultrasound (CEUS) has become the preferred method for many clinicians in evaluating focal liver lesions (FLLs) initially identified through standard ultrasound. However, in clinical practice, certain lesions may deviate from the typical enhancement pa...
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MDPI AG
2024-12-01
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| author | Tudor Voicu Moga Raluca Lupusoru Mirela Danila Ana Maria Ghiuchici Alina Popescu Bogdan Miutescu Iulia Ratiu Calin Burciu Teofana Bizerea-Moga Anca Voron Ioan Sporea Roxana Sirli |
| author_facet | Tudor Voicu Moga Raluca Lupusoru Mirela Danila Ana Maria Ghiuchici Alina Popescu Bogdan Miutescu Iulia Ratiu Calin Burciu Teofana Bizerea-Moga Anca Voron Ioan Sporea Roxana Sirli |
| author_sort | Tudor Voicu Moga |
| collection | DOAJ |
| description | <b>Background:</b> Contrast-enhanced ultrasound (CEUS) has become the preferred method for many clinicians in evaluating focal liver lesions (FLLs) initially identified through standard ultrasound. However, in clinical practice, certain lesions may deviate from the typical enhancement patterns outlined in EFSUMB guidelines. <b>Methods:</b> This study aims to assess FLLs that remained inconclusive or misdiagnosed after CEUS evaluation, spanning eight years of single-center experience. Following CEUS, all FLLs underwent secondary imaging (CT, MRI) or histopathological analysis for diagnostic confirmation. <b>Results:</b> From the initial 979 FLLs, 350 lesions (35.7%) were either inconclusive or misdiagnosed by CEUS, with hepatocellular carcinoma (HCC) and liver metastases constituting the majority of these cases. The most frequent enhancement pattern in inconclusive lesions at CEUS was hyper-iso-iso. Factors such as advanced liver fibrosis, adenomas, and cholangiocarcinoma were significantly associated with higher rates of diagnostic inaccuracies. <b>Conclusions:</b> Advanced liver fibrosis, adenomas, and cholangiocarcinoma were significantly associated with increased diagnostic challenges, emphasizing the need for supplementary imaging techniques. |
| format | Article |
| id | doaj-art-aacf91c0166643f294f8f99d4397b6b0 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-aacf91c0166643f294f8f99d4397b6b02025-01-10T13:16:33ZengMDPI AGDiagnostics2075-44182024-12-011514610.3390/diagnostics15010046Challenges in Diagnosing Focal Liver Lesions Using Contrast-Enhanced UltrasoundTudor Voicu Moga0Raluca Lupusoru1Mirela Danila2Ana Maria Ghiuchici3Alina Popescu4Bogdan Miutescu5Iulia Ratiu6Calin Burciu7Teofana Bizerea-Moga8Anca Voron9Ioan Sporea10Roxana Sirli11Department of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaCenter of Advanced Research in Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Pediatrics-1st Pediatric Discipline, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaCenter of Advanced Research in Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaDepartment of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania<b>Background:</b> Contrast-enhanced ultrasound (CEUS) has become the preferred method for many clinicians in evaluating focal liver lesions (FLLs) initially identified through standard ultrasound. However, in clinical practice, certain lesions may deviate from the typical enhancement patterns outlined in EFSUMB guidelines. <b>Methods:</b> This study aims to assess FLLs that remained inconclusive or misdiagnosed after CEUS evaluation, spanning eight years of single-center experience. Following CEUS, all FLLs underwent secondary imaging (CT, MRI) or histopathological analysis for diagnostic confirmation. <b>Results:</b> From the initial 979 FLLs, 350 lesions (35.7%) were either inconclusive or misdiagnosed by CEUS, with hepatocellular carcinoma (HCC) and liver metastases constituting the majority of these cases. The most frequent enhancement pattern in inconclusive lesions at CEUS was hyper-iso-iso. Factors such as advanced liver fibrosis, adenomas, and cholangiocarcinoma were significantly associated with higher rates of diagnostic inaccuracies. <b>Conclusions:</b> Advanced liver fibrosis, adenomas, and cholangiocarcinoma were significantly associated with increased diagnostic challenges, emphasizing the need for supplementary imaging techniques.https://www.mdpi.com/2075-4418/15/1/46focal liver lesionscontrast-enhanced ultrasound (CEUS)hepatocellular carcinoma (HCC) diagnosis |
| spellingShingle | Tudor Voicu Moga Raluca Lupusoru Mirela Danila Ana Maria Ghiuchici Alina Popescu Bogdan Miutescu Iulia Ratiu Calin Burciu Teofana Bizerea-Moga Anca Voron Ioan Sporea Roxana Sirli Challenges in Diagnosing Focal Liver Lesions Using Contrast-Enhanced Ultrasound Diagnostics focal liver lesions contrast-enhanced ultrasound (CEUS) hepatocellular carcinoma (HCC) diagnosis |
| title | Challenges in Diagnosing Focal Liver Lesions Using Contrast-Enhanced Ultrasound |
| title_full | Challenges in Diagnosing Focal Liver Lesions Using Contrast-Enhanced Ultrasound |
| title_fullStr | Challenges in Diagnosing Focal Liver Lesions Using Contrast-Enhanced Ultrasound |
| title_full_unstemmed | Challenges in Diagnosing Focal Liver Lesions Using Contrast-Enhanced Ultrasound |
| title_short | Challenges in Diagnosing Focal Liver Lesions Using Contrast-Enhanced Ultrasound |
| title_sort | challenges in diagnosing focal liver lesions using contrast enhanced ultrasound |
| topic | focal liver lesions contrast-enhanced ultrasound (CEUS) hepatocellular carcinoma (HCC) diagnosis |
| url | https://www.mdpi.com/2075-4418/15/1/46 |
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