METTL3 promotes the osteogenic differentiation of periosteum-derived MSCs via regulation of the HOXD8/ITGA5 axis in congenital pseudarthrosis

METTL3 promotes the osteogenic differentiation of periosteum-derived MSCs via regulation of the HOXD8/ITGA5 axis in congenital pseudarthrosis

Background: Congenital pseudarthrosis of the tibia (CPT) is a dominant health challenge in pediatric orthopedics. The essential process in the development of CPT is the limited capacity of mesenchymal stem cells (MSCs) derived from CPT to undergo osteogenic differentiation. Our research aimed to elu...

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Bibliographic Details
Main Authors: Weihua Ye, Zheng Liu, Yaoxi Liu, Han Xiao, Qian Tan, An Yan, Guanghui Zhu
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Regenerative Therapy
Subjects:
CPT MSCs
METTL3
HOXD8
ITGA5
Osteogenic differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S235232042400066X
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