Unusual phenomenon in advanced hepatocellular carcinoma: declining alpha-fetoprotein levels despite disease progression

Abstract In advanced hepatocellular carcinoma (HCC), some patients exhibit declining serum alpha-fetoprotein (AFP) levels despite disease progression. We investigated the characteristics, outcomes, and potential causes of this unusual phenomenon. We conducted a retrospective analysis of 139 patients...

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Bibliographic Details
Main Authors: Haoran Shi, Xing Gao, Pan Liu, Lulu Xing, Zhixuan Qin, Yanfeng Pan
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Discover Oncology
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Online Access:https://doi.org/10.1007/s12672-025-02972-8
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