Removal of promoter CpG methylation by epigenome editing reverses HBG silencing

Removal of promoter CpG methylation by epigenome editing reverses HBG silencing

Abstract β-hemoglobinopathies caused by mutations in adult-expressed HBB can be treated by re-activating the adjacent paralogous genes HBG1 and HBG2 (HBG), which are normally silenced perinatally. Although HBG expression is induced by global demethylating drugs, their mechanism is poorly understood,...

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Main Authors: Henry W. Bell, Ruopeng Feng, Manan Shah, Yu Yao, James Douglas, Phillip A. Doerfler, Thiyagaraj Mayuranathan, Michael F. O’Dea, Yichao Li, Yong-Dong Wang, Jingjing Zhang, Joel P. Mackay, Yong Cheng, Kate G. R. Quinlan, Mitchell J. Weiss, Merlin Crossley
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62177-z
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https://doi.org/10.1038/s41467-025-62177-z

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