Identification and characterization of forced degradation products of lumateperone tosylate by LC-HRMS, GC-MS, NMR, and in silico toxicity prediction

Identification and characterization of forced degradation products of lumateperone tosylate by LC-HRMS, GC-MS, NMR, and in silico toxicity prediction

This study presents a detailed forced degradation profiling of lumateperone under stress conditions to develop a stability-indicating method capable of separating degradation products (DP-1 to DP-11), followed by their identification and characterization using hyphenated analytical techniques. Signi...

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Bibliographic Details
Main Authors: Nehal Bhatt, Devendra Sonaje, Vijiaya Madhyanapu Golla, Rahul Khemchandani, Roshitha K. R, Arun Kumar Gupta, Gananadhamu Samanthula
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Journal of Pharmaceutical and Biomedical Analysis Open
Subjects:
Lumateperone tosylate
Stress study
Degradation products
LC-HRMS
NMR spectroscopy
GC-MS
Online Access:http://www.sciencedirect.com/science/article/pii/S2949771X25000362
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