A second photoactivatable state of the anion-conducting channelrhodopsin GtACR1 empowers persistent activity

Abstract Optogenetics is a method to regulate cells, tissues and organisms using light. It is applied to study neurons and to develop diagnostic and therapeutic tools for neuron-related diseases. The cation-conducting channelrhodopsin ChR2 triggers photoinduced depolarization of neuronal cells but g...

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Bibliographic Details
Main Authors: Kristin Labudda, Mohamad Javad Norahan, Lisa-Marie Hübner, Philipp Althoff, Klaus Gerwert, Mathias Lübben, Till Rudack, Carsten Kötting
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08560-4
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