Targeting Piezo1 channel to alleviate intervertebral disc degeneration

Targeting Piezo1 channel to alleviate intervertebral disc degeneration

Background: Low back pain impacts over 600 million people worldwide, predominantly due to intervertebral disc degeneration. This study focuses on the role of Piezo1, a crucial mechanosensitive ion channel protein, in the pathology and potential treatment of disc degeneration. Materials and methods:...

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Bibliographic Details
Main Authors: Feiyun Li, Mingjue Chen, Mengrui Zhang, Sheng Chen, Minghao Qu, Shuangshuang He, Lin Wang, Xiaohao Wu, Guozhi Xiao
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Journal of Orthopaedic Translation
Subjects:
Piezo1
Intervertebral disc degeneration
Lumbar spine instability
Aging
GsMTx4
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X25000075
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