Pyrrolopyrimidines: Design, Synthesis and Antitumor Properties of Novel Tricyclic Pyrrolo [2,3-<i>d</i>]pyrimidine Derivatives

Pyrrolopyrimidines: Design, Synthesis and Antitumor Properties of Novel Tricyclic Pyrrolo [2,3-<i>d</i>]pyrimidine Derivatives

The pyrrolo[2,3-<i>d</i>]pyrimidine (7-deazapurine) scaffold is a unique heterocyclic system included in the composition of most nucleotides. In this study, series of the pyrrolo[2,3-<i>d</i>]pyrimidine-imines and 3-<i>halo</i>-substituted pyrrolo[2,3-<i>d&l...

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Bibliographic Details
Main Authors: Buer Song, Zarifa Murtazaeva, Lifei Nie, Rustamkhon Kuryazov, Shukhrat Gaybullaev, Chao Niu, Khurshed Bozorov, Haji Akber Aisa, Jiangyu Zhao
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
antitumor activity
carbonyl-amine condensation
DDR2 receptor
HT-29 cell line
molecular docking
<i>N</i>-halosuccinimide
Online Access:https://www.mdpi.com/1420-3049/30/14/2917
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