Improvements in Bone Disorganization and Pseudo-Fracture Healing in Hypophosphatasia Following Asfotase Alfa Therapy May Be Detectable by the ALIGNOGRAM Before Changes in Bone Radiography or Scintigraphy

Improvements in Bone Disorganization and Pseudo-Fracture Healing in Hypophosphatasia Following Asfotase Alfa Therapy May Be Detectable by the ALIGNOGRAM Before Changes in Bone Radiography or Scintigraphy

Hypophosphatasia (HPP) is a rare genetic disorder characterized by bone fragility due to defective bone mineralization resulting in impaired alignment of bone components (bone disorganization). Current challenges in the management of HPP include accurately quantifying bone disease severity, monitori...

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Main Authors: Roger Zebaze, Simon Zhang, Cat Shore-Lorenti, Cherie Chiang, Frances Milat, Peter Ebeling
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Case Reports in Endocrinology
Online Access:http://dx.doi.org/10.1155/crie/5583096
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http://dx.doi.org/10.1155/crie/5583096

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