Exploring novel and potent glycogen synthase kinase-3β inhibitors through systematic drug designing approach

Exploring novel and potent glycogen synthase kinase-3β inhibitors through systematic drug designing approach

Abstract Significant implications of glycogen synthase kinase-3β (GSK-3β) have been reported in various neuronal disorders and malignant cancers. GSK-3β modulates diverse protein targets through phosphorylation, and its aberrant activity leads to neurological complications as well as tumour onset. T...

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Bibliographic Details
Main Authors: Shabir Ahmad Ganai, Suma Mohan, Shahid Ahmad Padder
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
GSK-3β
Shape based screening
XP-docking
Trajectory clustering
Molecular dynamics simulation
e-Pharmacophores modelling
Online Access:https://doi.org/10.1038/s41598-025-85868-5
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https://doi.org/10.1038/s41598-025-85868-5

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