Immune counter-evolution: immortalized B cell clones can undergo ex vivo directed evolution to counteract viral escape

Immune counter-evolution: immortalized B cell clones can undergo ex vivo directed evolution to counteract viral escape

IntroductionAmid the persistent threat of future pandemics, the continuous evolution of SARS-CoV-2 exposed critical challenges for vaccine efficacy and therapeutic interventions, highlighting the need for rapid and adaptable approaches to respond to immune escape variants.MethodsHere, we report the...

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Bibliographic Details
Main Authors: Casper Marsman, Jurgen Heinen, Vanessa Clerico Mosina, Kelly Maijoor, Arjen Q. Bakker, Michael Koslowski, Alessandra Villa, Stefano Gullà
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
human B cell
antibody discovery
affinity maturation
directed evolution
biparatopic antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1648717/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1648717/full

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