Sensory neuron–specific block of multifaceted sodium channels mitigates neuropathic pain behaviors of osteoarthritis

Objective:. Multiple voltage-gated sodium channels (NaVs) in the peripheral sensory neurons (PSNs) regulate action potentials and their dysfunction contributes to the pain pathogenesis of osteoarthritis (OA). A combined block of multiple NaV subtypes selectively in the PSNs may, therefore, represent...

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Bibliographic Details
Main Authors: Seung Min Shin, Brandon Itson-Zoske, Hao Xu, Hongfei Xiang, Fan Fan, Quinn H. Hogan, Hongwei Yu
Format: Article
Language:English
Published: Wolters Kluwer 2025-08-01
Series:PAIN Reports
Online Access:http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000001288
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