COL6A2 in clear cell renal cell carcinoma: a multifaceted driver of tumor progression, immune evasion, and drug sensitivity

COL6A2 in clear cell renal cell carcinoma: a multifaceted driver of tumor progression, immune evasion, and drug sensitivity

Abstract Background Renal Cell Carcinoma (RCC) is a leading cause of cancer-related mortality worldwide, with Clear Cell Renal Cell Carcinoma (ccRCC) comprising 75% of cases. Surgical resection remains the cornerstone of treatment for localized RCC, but its asymptomatic progression and lack of relia...

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Bibliographic Details
Main Authors: Yashuang Yang, Ruixin Fan, Boming Zhang, Kai Liu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Renal cancer
COL6A2
Tumor microenvironment
Pharmacological prediction
Prognostic significance
Online Access:https://doi.org/10.1186/s12967-025-06793-9
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https://doi.org/10.1186/s12967-025-06793-9

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