Multi-Modal Design, Synthesis, and Biological Evaluation of Novel Fusidic Acid Derivatives

Multi-Modal Design, Synthesis, and Biological Evaluation of Novel Fusidic Acid Derivatives

Fusidic acid (FA), a tetracyclic triterpenoid, has been approved to treat methicillin-resistant Staphylococcus aureus (MRSA) infections. However, there are few reports about FA derivatives with high efficacy superior to FA, manifesting the difficulty of discovering the derivatives based on experienc...

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Bibliographic Details
Main Authors: Luqi Wang, Zhiyuan Geng, Yuhang Liu, Linhui Cao, Yao Liu, Hourui Zhang, Yi Bi, Jing Lu
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Molecules
Subjects:
fusidic acid derivative
molecular dynamics simulation
AI-based drug design and screening
in vitro model
Online Access:https://www.mdpi.com/1420-3049/30/9/1983
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