Advanced tissue technologies of blood-brain barrier organoids as high throughput toxicity readouts in drug development
Recent advancements in engineering Complex in vitro models (CIVMs) such as Blood-brain barrier (BBB) organoids offer promising platforms for preclinical drug testing. However, their application in drug development, and especially for the regulatory purposes of toxicity assessment, requires robust an...
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Main Authors: | Luisa Bell, Claire Simonneau, Chiara Zanini, Elena Kassianidou, Christelle Zundel, Rachel Neff, Bernd Steinhuber, Marco Tecilla, Alex Odermatt, Roberto Villaseñor, Nadine Stokar-Regenscheit |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2025-01-01
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Series: | Heliyon |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024168442 |
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