Single-cell and spatial transcriptomics reveal a stress-induced EMT-like epithelial subset driving immune activation in silica-injured lung

Single-cell and spatial transcriptomics reveal a stress-induced EMT-like epithelial subset driving immune activation in silica-injured lung

The mechanism that lung epithelial cells regulate immune responses during chronic injury still remains unclear. Here, we combined single-cell RNA sequencing with spatial transcriptomics to track epithelial dynamics in silica (SiO2)-exposed mouse lungs. By day 56, SiO2 induced significant epithelial...

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Bibliographic Details
Main Authors: Tao Wang, Jianfeng Hao, Bing Li, Ahjol Hyraht, Jialing Wang, Henglei Xia, Qingbin Wu, Wei Gao, Congxia Chen, Chuanqing Yu, Xiuqun Gong, Ting Li, Mei Zhang, Yinghai Xie, Xinrong Tao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
silicosis
alveolar epithelial cells
single-cell RNA sequencing
spatial transcriptomics
epithelial-immune crosstalk
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609616/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609616/full

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