An improved immunoassay detects Aβ oligomers in human biofluids: their CSF levels rise with tau and phosphotau levels

An improved immunoassay detects Aβ oligomers in human biofluids: their CSF levels rise with tau and phosphotau levels

Abstract Background Diffusible Aβ oligomers (oAβ) confer cytotoxicity in Alzheimer’s disease. The dynamic complexity of this hydrophobic analyte means few immunoassays exist to quantify oAβ in CSF and plasma. Methods We characterized antibody 71A1 to a cyclized dimer of Aβ9-18 for oAβ preference ove...

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Bibliographic Details
Main Authors: Ting Yang, Yi Ran Xu, Shanxue Jin, Nagendran Ramalingam, Jean-Pierre Bellier, Alexandra M. Lish, Beth L. Ostaszewski, Tracy Young-Pearse, Lei Liu, Hyun-Sik Yang, Jasmeer P. Chhatwal, Trebor L. Lawton, Dennis J. Selkoe
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Biomarkers
Amyloid β-protein
Oligomeric Aβ
Tau
Monitoring
Online Access:https://doi.org/10.1186/s13195-025-01802-x
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