Geranylgeranyl diphosphate synthase deficiency impairs efferocytosis and resolution of acute lung injury

Abstract Acute respiratory distress syndrome (ARDS) are major causes of mortality of critically ill patients. Impaired macrophage-mediated clearance of apoptotic cells (efferocytosis) in ARDS contributes to prolonged inflammation, yet the underlying mechanisms remain unclear. In this study, we inves...

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Main Authors: Jiajia Jin, Lihong Ma, Lulu Li, Xinyu Zhou, Suhua Zhu, Kaikai Shen, Qiuli Xu, Bei Jiang, Yanli Gu, Qianshan Ding, Hong Qian, Tangfeng Lv, Yong Song
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Respiratory Research
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Online Access:https://doi.org/10.1186/s12931-025-03241-6
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