Geranylgeranyl diphosphate synthase deficiency impairs efferocytosis and resolution of acute lung injury

Geranylgeranyl diphosphate synthase deficiency impairs efferocytosis and resolution of acute lung injury

Abstract Acute respiratory distress syndrome (ARDS) are major causes of mortality of critically ill patients. Impaired macrophage-mediated clearance of apoptotic cells (efferocytosis) in ARDS contributes to prolonged inflammation, yet the underlying mechanisms remain unclear. In this study, we inves...

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Main Authors: Jiajia Jin, Lihong Ma, Lulu Li, Xinyu Zhou, Suhua Zhu, Kaikai Shen, Qiuli Xu, Bei Jiang, Yanli Gu, Qianshan Ding, Hong Qian, Tangfeng Lv, Yong Song
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Respiratory Research
Subjects:
Acute respiratory distress syndrome
Resolution
Efferocytosis
Macrophage
Geranylgeranyl diphosphate synthase
AXL
Online Access:https://doi.org/10.1186/s12931-025-03241-6
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