Development of mirror-image monobodies targeting the oncogenic BCR::ABL1 kinase

Development of mirror-image monobodies targeting the oncogenic BCR::ABL1 kinase

Abstract Mirror-image proteins, composed of d-amino acids, are an attractive therapeutic modality, as they exhibit high metabolic stability and lack immunogenicity. Development of mirror-image binding proteins is achieved through chemical synthesis of d-target proteins, phage display library selecti...

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Main Authors: Nina Schmidt, Amit Kumar, Lukas Korf, Adrian Valentin Dinh-Fricke, Frank Abendroth, Akiko Koide, Uwe Linne, Magdalena Rakwalska-Bange, Shohei Koide, Lars-Oliver Essen, Olalla Vázquez, Oliver Hantschel
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54901-y
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https://doi.org/10.1038/s41467-024-54901-y

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