Clusterin induced by OPC phagocytosis blocks IL-9 secretion to inhibit myelination in a model of Alzheimer's disease

Clusterin induced by OPC phagocytosis blocks IL-9 secretion to inhibit myelination in a model of Alzheimer's disease

Background: Variants in the CLUSTERIN gene have been identified as a risk factor for late-onset Alzheimer's disease and are linked to decreased white matter integrity in healthy adults. However, the specific role for clusterin in myelin maintenance in the context of Alzheimer's disease rem...

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Bibliographic Details
Main Authors: Rebecca M. Beiter, Tula P. Raghavan, Olivia Suchocki, Hannah E. Ennerfelt, Courtney R. Rivet-Noor, Andrea R. Merchak, Jennifer L. Phillips, Tim Bathe, John R. Lukens, Stefan Prokop, Jeffrey L. Dupree, Alban Gaultier
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Subjects:
Oligodendrocyte progenitor cells
Astrocyte
Clusterin
Myelin
Alzheimer's disease
IL-9
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025000143
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