IgG1 versus IgG3: influence of antibody-specificity and allotypic variance on virus neutralization efficacy

IgG1 versus IgG3: influence of antibody-specificity and allotypic variance on virus neutralization efficacy

Despite the unique advantages of IgG3 over other IgG subclasses, such as mediating enhanced effector functions and increased flexibility in antigen binding due to a long hinge region, the therapeutic potential of IgG3 remains largely unexplored. This may be attributed to difficulties in recombinant...

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Main Authors: Somanath Kallolimath, Lin Sun, Roman Palt, Esther Föderl-Höbenreich, Antonia Hermle, Leonie Voss, Marina Kleim, Falk Nimmerjahn, Johannes S. Gach, Lauren Hitchcock, Qiang Chen, Stanislav Melnik, Florian Eminger, Anja Lux, Herta Steinkellner
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Immunology
Subjects:
IgG3 allotypes
plant expression
SARS-CoV-2 antibodies
functional activities
antibody engineering
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490515/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490515/full

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