Neuronal TDP-43 aggregation drives changes in microglial morphology prior to immunophenotype in amyotrophic lateral sclerosis

Neuronal TDP-43 aggregation drives changes in microglial morphology prior to immunophenotype in amyotrophic lateral sclerosis

Abstract Microglia are the innate immune cells of the brain with the capacity to react to damage or disease. Microglial reactions can be characterised in post-mortem tissues by assessing their pattern of protein expression, or immunophenotypes, and cell morphologies. We recently demonstrated that mi...

Full description

Saved in:
Bibliographic Details
Main Authors: Molly E. V. Swanson, Miran Mrkela, Clinton Turner, Maurice A. Curtis, Richard L. M. Faull, Adam K. Walker, Emma L. Scotter
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Acta Neuropathologica Communications
Subjects:
Amyotrophic lateral sclerosis
Microglia
TDP-43
Iba1
CD68
Ramified
Online Access:https://doi.org/10.1186/s40478-025-01941-0
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s40478-025-01941-0

Similar Items