Applying integrated transcriptome and single-cell sequencing analysis to develop a prognostic signature based on M2-like tumor-associated macrophages for breast cancer

Applying integrated transcriptome and single-cell sequencing analysis to develop a prognostic signature based on M2-like tumor-associated macrophages for breast cancer

Abstract Background M2-like tumor-associated macrophages (M2-like TAMs) function crucially in the tumor microenvironment (TME) and cancer development. This study developed a prognostic signature based on M2-like TAM-related genes for breast cancer (BRCA) applying transcriptome and scRNA-seq analysis...

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Bibliographic Details
Main Authors: Yanghaochen Xu, Peiyan Lin, Ye Zhu, Qing Zhang, Jinhong Zhou
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Discover Oncology
Subjects:
Breast cancer
M2 macrophages
Tumor microenvironment
Immune-related genes
Prognosis
Therapeutic targets
Online Access:https://doi.org/10.1007/s12672-025-02161-7
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https://doi.org/10.1007/s12672-025-02161-7

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