Development of an innovative duplex digital PCR assay for circulating MiRNA ratio quantification in metastatic melanoma

Development of an innovative duplex digital PCR assay for circulating MiRNA ratio quantification in metastatic melanoma

Abstract Background Circulating miRNAs (cmiRNAs) are emerging as valuable non-invasive biomarkers for monitoring disease progression and therapeutic response in cancer. Their stability in biological fluids, tissue-specific expression, and functional roles in tumor biology make them particularly suit...

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Main Authors: Alex De Gregorio, Andrea Sacconi, Chiara Mandoj, Fabio Valenti, Valentina De Pascale, Gabriele Madonna, Mariaelena Capone, Teresa Meinardi, Francesca Guerresi, Irene Terrenato, Giovanni Cigliana, Michelangelo Russillo, Virginia Ferraresi, Maurizio Fanciulli, Giovanni Blandino, Paolo Antonio Ascierto, Gennaro Ciliberto, Rita Mancini, Luigi Fattore
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Digital PCR
Duplex assay
Liquid biopsy
Circulating MiRNAs
Metastatic melanoma
Online Access:https://doi.org/10.1186/s12967-025-06941-1
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https://doi.org/10.1186/s12967-025-06941-1

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