DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells

DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells

Summary: Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitors are widely applied to maintain pluripotency, while prolonged MEK inhibition compromises the developmental potential of mouse embryonic stem cells (ESCs). To understand the mechanism of MEK in pluripotency maintenance,...

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Bibliographic Details
Main Authors: Jiayu Yu, Nannan Zhao, Yuying Wang, Nan Ding, Zhenchang Guo, Zichan He, Qingye Zhang, Jingai Zhang, Xiaoqiong Yang, Ming Zhang, Xiaoling Du, Kai Zhang, Lingyi Chen
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Cell Reports
Subjects:
CP: Stem cell research
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724014098
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