Assessing Changes in Motor Function and Mobility in Individuals with Parkinson’s Disease After 12 Sessions of Patient-Specific Adaptive Dynamic Cycling
Background and Purpose: This pilot randomized controlled trial evaluated the effects of 12 sessions of patient-specific adaptive dynamic cycling (PSADC) versus non-adaptive cycling (NA) on motor function and mobility in individuals with Parkinson’s disease (PD), using inertial measurement unit (IMU)...
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MDPI AG
2024-11-01
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| Online Access: | https://www.mdpi.com/1424-8220/24/22/7364 |
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| author | Younguk Kim Brittany E. Smith Lara Shigo Aasef G. Shaikh Kenneth A. Loparo Angela L. Ridgel |
| author_facet | Younguk Kim Brittany E. Smith Lara Shigo Aasef G. Shaikh Kenneth A. Loparo Angela L. Ridgel |
| author_sort | Younguk Kim |
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| description | Background and Purpose: This pilot randomized controlled trial evaluated the effects of 12 sessions of patient-specific adaptive dynamic cycling (PSADC) versus non-adaptive cycling (NA) on motor function and mobility in individuals with Parkinson’s disease (PD), using inertial measurement unit (IMU) sensors for objective assessment. Methods: Twenty-three participants with PD (13 in the PSADC group and 10 in the NA group) completed the study over a 4-week period. Motor function was measured using the Kinesia™ sensors and the MDS-UPDRS Motor III, while mobility was assessed with the TUG test using OPAL IMU sensors. Results: The PSADC group showed significant improvements in MDS-UPDRS Motor III scores (<i>t</i> = 5.165, <i>p</i> < 0.001) and dopamine-sensitive symptoms (<i>t</i> = 4.629, <i>p</i> = 0.001), whereas the NA group did not improve. Both groups showed non-significant improvements in TUG time. IMU sensors provided continuous, quantitative, and unbiased measurements of motor function and mobility, offering a more precise and objective tracking of improvements over time. Conclusions: PSADC demonstrated enhanced treatment effects on PD motor function compared to NA while also reducing variability in individual responses. The integration of IMU sensors was essential for precise monitoring, supporting the potential of a data-driven, individualized exercise approach to optimize treatment outcomes for individuals with PD. |
| format | Article |
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| institution | Kabale University |
| issn | 1424-8220 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-a857b584490e4fcd95b0bb379f6052ad2024-11-26T18:21:43ZengMDPI AGSensors1424-82202024-11-012422736410.3390/s24227364Assessing Changes in Motor Function and Mobility in Individuals with Parkinson’s Disease After 12 Sessions of Patient-Specific Adaptive Dynamic CyclingYounguk Kim0Brittany E. Smith1Lara Shigo2Aasef G. Shaikh3Kenneth A. Loparo4Angela L. Ridgel5Exercise Science and Exercise Physiology Program, Kent State University, Kent, OH 44242, USAExercise Science and Exercise Physiology Program, Kent State University, Kent, OH 44242, USAExercise Science and Exercise Physiology Program, Kent State University, Kent, OH 44242, USADepartment of Neurology, Case Western Reserve University, Cleveland, OH 44106, USAInstitute for Smart, Secure and Connected Systems, Case Western Reserve University, Cleveland, OH 44106, USAExercise Science and Exercise Physiology Program, Kent State University, Kent, OH 44242, USABackground and Purpose: This pilot randomized controlled trial evaluated the effects of 12 sessions of patient-specific adaptive dynamic cycling (PSADC) versus non-adaptive cycling (NA) on motor function and mobility in individuals with Parkinson’s disease (PD), using inertial measurement unit (IMU) sensors for objective assessment. Methods: Twenty-three participants with PD (13 in the PSADC group and 10 in the NA group) completed the study over a 4-week period. Motor function was measured using the Kinesia™ sensors and the MDS-UPDRS Motor III, while mobility was assessed with the TUG test using OPAL IMU sensors. Results: The PSADC group showed significant improvements in MDS-UPDRS Motor III scores (<i>t</i> = 5.165, <i>p</i> < 0.001) and dopamine-sensitive symptoms (<i>t</i> = 4.629, <i>p</i> = 0.001), whereas the NA group did not improve. Both groups showed non-significant improvements in TUG time. IMU sensors provided continuous, quantitative, and unbiased measurements of motor function and mobility, offering a more precise and objective tracking of improvements over time. Conclusions: PSADC demonstrated enhanced treatment effects on PD motor function compared to NA while also reducing variability in individual responses. The integration of IMU sensors was essential for precise monitoring, supporting the potential of a data-driven, individualized exercise approach to optimize treatment outcomes for individuals with PD.https://www.mdpi.com/1424-8220/24/22/7364wearable technologyneurorehabilitationmotor controlmovement disorders |
| spellingShingle | Younguk Kim Brittany E. Smith Lara Shigo Aasef G. Shaikh Kenneth A. Loparo Angela L. Ridgel Assessing Changes in Motor Function and Mobility in Individuals with Parkinson’s Disease After 12 Sessions of Patient-Specific Adaptive Dynamic Cycling Sensors wearable technology neurorehabilitation motor control movement disorders |
| title | Assessing Changes in Motor Function and Mobility in Individuals with Parkinson’s Disease After 12 Sessions of Patient-Specific Adaptive Dynamic Cycling |
| title_full | Assessing Changes in Motor Function and Mobility in Individuals with Parkinson’s Disease After 12 Sessions of Patient-Specific Adaptive Dynamic Cycling |
| title_fullStr | Assessing Changes in Motor Function and Mobility in Individuals with Parkinson’s Disease After 12 Sessions of Patient-Specific Adaptive Dynamic Cycling |
| title_full_unstemmed | Assessing Changes in Motor Function and Mobility in Individuals with Parkinson’s Disease After 12 Sessions of Patient-Specific Adaptive Dynamic Cycling |
| title_short | Assessing Changes in Motor Function and Mobility in Individuals with Parkinson’s Disease After 12 Sessions of Patient-Specific Adaptive Dynamic Cycling |
| title_sort | assessing changes in motor function and mobility in individuals with parkinson s disease after 12 sessions of patient specific adaptive dynamic cycling |
| topic | wearable technology neurorehabilitation motor control movement disorders |
| url | https://www.mdpi.com/1424-8220/24/22/7364 |
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