Design and Synthesis of 7-(N-Aryl Pyrrolidinyl) Indoles as Potential DCAF15 Binders

Design and Synthesis of 7-(N-Aryl Pyrrolidinyl) Indoles as Potential DCAF15 Binders

We describe the design and synthesis of a series of 7-(N-aryl pyrrolidinyl) indoles and oxo-analogs as isosteric mimics of the DCAF15 binder E7820, a well-known member of aryl sulfonamides known as SPLAMs. The functionalization of C-7 in indoles was achieved by metal-catalyzed CH-activation with une...

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Bibliographic Details
Main Authors: Ravi Devarajappa, Scarlett Kiyeleko, Sofiane Hocine, Victor Cosson, Remi Calandrino, Timea Baló, Jayson Alves Bordelo, Sébastien Triboulet, Laure Caruana, Laurence Klipfel, Sandrine Calis, András Herner, Stephen Hanessian
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Reactions
Subjects:
molecular glues
DCAF15 binders
indole derivatives
Online Access:https://www.mdpi.com/2624-781X/6/1/20
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https://www.mdpi.com/2624-781X/6/1/20

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