Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors

Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors

Ras-ERK signalling in the brain plays a central role in drug addiction. However, to date, no clinically relevant inhibitor of this cascade has been tested in experimental models of addiction, a necessary step toward clinical trials. We designed two new cell-penetrating peptides - RB1 and RB3 - that...

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Main Authors: Alessandro Papale, Ilaria Maria Morella, Marzia Tina Indrigo, Rick Eugene Bernardi, Livia Marrone, Francesca Marchisella, Andrea Brancale, Rainer Spanagel, Riccardo Brambilla, Stefania Fasano
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-08-01
Series:eLife
Subjects:
Ras-ERK signalling
MEK inhibitor
cell-penetrating peptide
cocaine place preference
cocaine self-administration
Online Access:https://elifesciences.org/articles/17111
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https://elifesciences.org/articles/17111

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