Roles of hypoxia inducible factors in viral infection: Are they a potential therapeutic target?
As a crucial nuclear transcription factor, hypoxia-inducible factor (HIF) serves essential functions in mediating cellular responses to hypoxic stress. Through oxygen-sensing mechanisms, HIF initiates downstream signaling cascades that coordinate metabolic reprogramming, immune modulation, and oncog...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
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| Series: | Virulence |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2025.2546680 |
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| _version_ | 1849239529687351296 |
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| author | Sikai Jia Shuo Pan Zhiyun Gao Hongxiu Qiao Yan Zhao Xia Chuai Jian Li |
| author_facet | Sikai Jia Shuo Pan Zhiyun Gao Hongxiu Qiao Yan Zhao Xia Chuai Jian Li |
| author_sort | Sikai Jia |
| collection | DOAJ |
| description | As a crucial nuclear transcription factor, hypoxia-inducible factor (HIF) serves essential functions in mediating cellular responses to hypoxic stress. Through oxygen-sensing mechanisms, HIF initiates downstream signaling cascades that coordinate metabolic reprogramming, immune modulation, and oncogenic progression in oxygen-deficient microenvironments. Current evidence positions HIF at the convergence of various pathologies, including microbial pathogenesis, carcinogenesis, and inflammatory disorders. This systematic review summarizes recent advances in HIF-mediated immunomodulation and virological mechanisms. The analysis emphasizes the fundamental importance of investigating HIF-related molecular pathways to address significant gaps in basic research. |
| format | Article |
| id | doaj-art-a7957d7bf1cb427fb62d45a65bfe54bc |
| institution | Kabale University |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-a7957d7bf1cb427fb62d45a65bfe54bc2025-08-20T04:00:55ZengTaylor & Francis GroupVirulence2150-55942150-56082025-12-0116110.1080/21505594.2025.2546680Roles of hypoxia inducible factors in viral infection: Are they a potential therapeutic target?Sikai Jia0Shuo Pan1Zhiyun Gao2Hongxiu Qiao3Yan Zhao4Xia Chuai5Jian Li6Department of Pathogenic Biology, Hebei Medical University, Shijiazhuang, P. R. ChinaDepartment of Breast and Blood Radiation Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Pathogenic Biology, Hebei Medical University, Shijiazhuang, P. R. ChinaExperimental Center for Teaching, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Pathogenic Biology, Hebei Medical University, Shijiazhuang, P. R. ChinaState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega Science, Chinese Academy of Sciences, Wuhan, Hubei, P. R. ChinaDepartment of Pathogenic Biology, Hebei Medical University, Shijiazhuang, P. R. ChinaAs a crucial nuclear transcription factor, hypoxia-inducible factor (HIF) serves essential functions in mediating cellular responses to hypoxic stress. Through oxygen-sensing mechanisms, HIF initiates downstream signaling cascades that coordinate metabolic reprogramming, immune modulation, and oncogenic progression in oxygen-deficient microenvironments. Current evidence positions HIF at the convergence of various pathologies, including microbial pathogenesis, carcinogenesis, and inflammatory disorders. This systematic review summarizes recent advances in HIF-mediated immunomodulation and virological mechanisms. The analysis emphasizes the fundamental importance of investigating HIF-related molecular pathways to address significant gaps in basic research.https://www.tandfonline.com/doi/10.1080/21505594.2025.2546680Hypoxia inducible factorvirus infectionimmunizationhypoxianormoxia |
| spellingShingle | Sikai Jia Shuo Pan Zhiyun Gao Hongxiu Qiao Yan Zhao Xia Chuai Jian Li Roles of hypoxia inducible factors in viral infection: Are they a potential therapeutic target? Virulence Hypoxia inducible factor virus infection immunization hypoxia normoxia |
| title | Roles of hypoxia inducible factors in viral infection: Are they a potential therapeutic target? |
| title_full | Roles of hypoxia inducible factors in viral infection: Are they a potential therapeutic target? |
| title_fullStr | Roles of hypoxia inducible factors in viral infection: Are they a potential therapeutic target? |
| title_full_unstemmed | Roles of hypoxia inducible factors in viral infection: Are they a potential therapeutic target? |
| title_short | Roles of hypoxia inducible factors in viral infection: Are they a potential therapeutic target? |
| title_sort | roles of hypoxia inducible factors in viral infection are they a potential therapeutic target |
| topic | Hypoxia inducible factor virus infection immunization hypoxia normoxia |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2025.2546680 |
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