Association between daily sitting time and breast cancer among obese women: a nationwide population-based study
Abstract Background We aimed to explore the association between daily sitting time and breast cancer in obese women, and further examine the mitigating role of physical activity in this relationship. Materials and methods A secondary analysis of cross-sectional data from the National Health and Nutr...
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BMC
2025-07-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-025-03894-x |
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| author | Lizhen Wang Cuiwei Lai Zhipeng Wu Haoyue Luo Tai Xu |
| author_facet | Lizhen Wang Cuiwei Lai Zhipeng Wu Haoyue Luo Tai Xu |
| author_sort | Lizhen Wang |
| collection | DOAJ |
| description | Abstract Background We aimed to explore the association between daily sitting time and breast cancer in obese women, and further examine the mitigating role of physical activity in this relationship. Materials and methods A secondary analysis of cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 1999–2020 were used. Subjects were divided into four groups based on the duration of daily sitting time (< 4, 4 to 6, 6 to 8, and > 8 h). Survey-based logistic regression models, smooth curve fitting, subgroup analysis and sensitivity analysis were conducted. Results A total of 9706 obese females (mean age 50.28 years) were included in the study. Breast cancer was reported by 271 (2.8%) individuals. In the fully adjusted model, compared with those with < 4 h of daily sitting time, ORs (95%CI) for breast cancer were 1.61 (95%CI: 1.41–5.33, p = 0.001) in group with 4 to 6 h of sitting, 1.86 (95%CI: 1.35 to 4.52) in group with 6 to 8 h, and 2.21 (95%CI: 1.36–4.95, p = 0.008) with > 8 h per day. Of note, the detrimental effects of prolonged sedentary behavior on increased prevalence of breast cancer were only found in physically inactive group, but not in physically active group. Smooth curve fitting showed a positive dose-response relationship between daily sitting time and breast cancer in total participants and physically inactive group. Furthermore, obese women aged 60 years or older, non-Hispanic white, and with more than a high school education, post-menopause, and with higher obesity levels were more likely to be affected by sedentary behavior. Conclusion Prolonged daily sitting time is associated with increased prevalence of breast cancer in obese women and being physically active may mitigate this association. Prospective studies are needed to further examine this association. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-a75a42cceca74156845f7c13c48ee6ec |
| institution | Kabale University |
| issn | 1472-6874 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj-art-a75a42cceca74156845f7c13c48ee6ec2025-08-20T04:02:56ZengBMCBMC Women's Health1472-68742025-07-0125111210.1186/s12905-025-03894-xAssociation between daily sitting time and breast cancer among obese women: a nationwide population-based studyLizhen Wang0Cuiwei Lai1Zhipeng Wu2Haoyue Luo3Tai Xu4Department of Breast Surgery, Meizhou People’s HospitalDepartment of Breast Surgery, Meizhou People’s HospitalXiangya School of Medicine, Central South UniversityDepartment of Breast Surgery, Meizhou People’s HospitalDepartment of Breast Surgery, Meizhou People’s HospitalAbstract Background We aimed to explore the association between daily sitting time and breast cancer in obese women, and further examine the mitigating role of physical activity in this relationship. Materials and methods A secondary analysis of cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 1999–2020 were used. Subjects were divided into four groups based on the duration of daily sitting time (< 4, 4 to 6, 6 to 8, and > 8 h). Survey-based logistic regression models, smooth curve fitting, subgroup analysis and sensitivity analysis were conducted. Results A total of 9706 obese females (mean age 50.28 years) were included in the study. Breast cancer was reported by 271 (2.8%) individuals. In the fully adjusted model, compared with those with < 4 h of daily sitting time, ORs (95%CI) for breast cancer were 1.61 (95%CI: 1.41–5.33, p = 0.001) in group with 4 to 6 h of sitting, 1.86 (95%CI: 1.35 to 4.52) in group with 6 to 8 h, and 2.21 (95%CI: 1.36–4.95, p = 0.008) with > 8 h per day. Of note, the detrimental effects of prolonged sedentary behavior on increased prevalence of breast cancer were only found in physically inactive group, but not in physically active group. Smooth curve fitting showed a positive dose-response relationship between daily sitting time and breast cancer in total participants and physically inactive group. Furthermore, obese women aged 60 years or older, non-Hispanic white, and with more than a high school education, post-menopause, and with higher obesity levels were more likely to be affected by sedentary behavior. Conclusion Prolonged daily sitting time is associated with increased prevalence of breast cancer in obese women and being physically active may mitigate this association. Prospective studies are needed to further examine this association. Clinical trial number Not applicable.https://doi.org/10.1186/s12905-025-03894-xDaily sitting timeBreast cancerNational health and nutrition examination survey (NHANES)Cross-sectionalObesityPhysical activity |
| spellingShingle | Lizhen Wang Cuiwei Lai Zhipeng Wu Haoyue Luo Tai Xu Association between daily sitting time and breast cancer among obese women: a nationwide population-based study BMC Women's Health Daily sitting time Breast cancer National health and nutrition examination survey (NHANES) Cross-sectional Obesity Physical activity |
| title | Association between daily sitting time and breast cancer among obese women: a nationwide population-based study |
| title_full | Association between daily sitting time and breast cancer among obese women: a nationwide population-based study |
| title_fullStr | Association between daily sitting time and breast cancer among obese women: a nationwide population-based study |
| title_full_unstemmed | Association between daily sitting time and breast cancer among obese women: a nationwide population-based study |
| title_short | Association between daily sitting time and breast cancer among obese women: a nationwide population-based study |
| title_sort | association between daily sitting time and breast cancer among obese women a nationwide population based study |
| topic | Daily sitting time Breast cancer National health and nutrition examination survey (NHANES) Cross-sectional Obesity Physical activity |
| url | https://doi.org/10.1186/s12905-025-03894-x |
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