IMMUNOLOGICAL EVOLUTION OF A COHORT OF HIV-2 INFECTED PATIENTS: PECULIARITIES OF AN UNDERESTIMATED INFECTION
"IMMUNOLOGICAL EVOLUTION OF A COHORT OF HIV-2 INFECTED PATIENTS: PECULIARITIES OF AN UNDERESTIMATED INFECTION" Human Immunodeficiency Virus type 2 (HIV-2) affects a minority of patients in Italy; nevertheless, the increasing migratory flow from higher prevalence areas led to the spread...
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| Language: | English |
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PAGEPress Publications
2022-02-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://mjhid.org/index.php/mjhid/article/view/4763 |
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| author | Emanuele Focà Benedetta Fumarola |
| author_facet | Emanuele Focà Benedetta Fumarola |
| author_sort | Emanuele Focà |
| collection | DOAJ |
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"IMMUNOLOGICAL EVOLUTION OF A COHORT OF HIV-2 INFECTED PATIENTS: PECULIARITIES OF AN UNDERESTIMATED INFECTION"
Human Immunodeficiency Virus type 2 (HIV-2) affects a minority of patients in Italy; nevertheless, the increasing migratory flow from higher prevalence areas led to the spread of this virus into our Country. We evaluate clinical, viro-immunological and therapeutic characteristics of patients with HIV-2 infection and HIV-1/HIV-2 dual-infection and the early treatment impact on overall survival and incidence of AIDS event.
Methods: We retrospectively analyzed all HIV-2 and HIV-1/HIV-2 positive patients followed in a large Italian clinic from January 1987 to December 2020. We recorded demographic, viro-immunological, clinical and therapeutics data. We performed a descriptive analysis followed by a longitudinal analysis to explore the factors associated with CD4+ lymphocyte trend; lastly, we studied in a multivariable model the possible predictors of death and AIDS in our cohort.
Results: 32 subjects were enrolled, 17 (53%) HIV-2 infected and 15 (46.8%) HIV-1/HIV-2 dual-infected; 12 patients were lost to follow up, while 3 died. We found a lack of HIV-2 viremia in 12/32 subjects (37.5%).Most of the patients at baseline had a good viro-immunological profile with HIV-2 RNA <200 copies/ml and CD4+ lymphocyte >200 cell/mcl.
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| format | Article |
| id | doaj-art-a7425fdedf8647418608050b0ce9d7fb |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-a7425fdedf8647418608050b0ce9d7fb2025-01-02T06:36:39ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062022-02-0114110.4084/MJHID.2022.016IMMUNOLOGICAL EVOLUTION OF A COHORT OF HIV-2 INFECTED PATIENTS: PECULIARITIES OF AN UNDERESTIMATED INFECTIONEmanuele Focà0Benedetta FumarolaUniversità di Brescia "IMMUNOLOGICAL EVOLUTION OF A COHORT OF HIV-2 INFECTED PATIENTS: PECULIARITIES OF AN UNDERESTIMATED INFECTION" Human Immunodeficiency Virus type 2 (HIV-2) affects a minority of patients in Italy; nevertheless, the increasing migratory flow from higher prevalence areas led to the spread of this virus into our Country. We evaluate clinical, viro-immunological and therapeutic characteristics of patients with HIV-2 infection and HIV-1/HIV-2 dual-infection and the early treatment impact on overall survival and incidence of AIDS event. Methods: We retrospectively analyzed all HIV-2 and HIV-1/HIV-2 positive patients followed in a large Italian clinic from January 1987 to December 2020. We recorded demographic, viro-immunological, clinical and therapeutics data. We performed a descriptive analysis followed by a longitudinal analysis to explore the factors associated with CD4+ lymphocyte trend; lastly, we studied in a multivariable model the possible predictors of death and AIDS in our cohort. Results: 32 subjects were enrolled, 17 (53%) HIV-2 infected and 15 (46.8%) HIV-1/HIV-2 dual-infected; 12 patients were lost to follow up, while 3 died. We found a lack of HIV-2 viremia in 12/32 subjects (37.5%).Most of the patients at baseline had a good viro-immunological profile with HIV-2 RNA <200 copies/ml and CD4+ lymphocyte >200 cell/mcl. http://mjhid.org/index.php/mjhid/article/view/4763HIV-1, HIV-2, AIDS, Italy, cARTHIV-1, HIV-2, AIDS, Italy, cART |
| spellingShingle | Emanuele Focà Benedetta Fumarola IMMUNOLOGICAL EVOLUTION OF A COHORT OF HIV-2 INFECTED PATIENTS: PECULIARITIES OF AN UNDERESTIMATED INFECTION Mediterranean Journal of Hematology and Infectious Diseases HIV-1, HIV-2, AIDS, Italy, cARTHIV-1, HIV-2, AIDS, Italy, cART |
| title | IMMUNOLOGICAL EVOLUTION OF A COHORT OF HIV-2 INFECTED PATIENTS: PECULIARITIES OF AN UNDERESTIMATED INFECTION |
| title_full | IMMUNOLOGICAL EVOLUTION OF A COHORT OF HIV-2 INFECTED PATIENTS: PECULIARITIES OF AN UNDERESTIMATED INFECTION |
| title_fullStr | IMMUNOLOGICAL EVOLUTION OF A COHORT OF HIV-2 INFECTED PATIENTS: PECULIARITIES OF AN UNDERESTIMATED INFECTION |
| title_full_unstemmed | IMMUNOLOGICAL EVOLUTION OF A COHORT OF HIV-2 INFECTED PATIENTS: PECULIARITIES OF AN UNDERESTIMATED INFECTION |
| title_short | IMMUNOLOGICAL EVOLUTION OF A COHORT OF HIV-2 INFECTED PATIENTS: PECULIARITIES OF AN UNDERESTIMATED INFECTION |
| title_sort | immunological evolution of a cohort of hiv 2 infected patients peculiarities of an underestimated infection |
| topic | HIV-1, HIV-2, AIDS, Italy, cARTHIV-1, HIV-2, AIDS, Italy, cART |
| url | http://mjhid.org/index.php/mjhid/article/view/4763 |
| work_keys_str_mv | AT emanuelefoca immunologicalevolutionofacohortofhiv2infectedpatientspeculiaritiesofanunderestimatedinfection AT benedettafumarola immunologicalevolutionofacohortofhiv2infectedpatientspeculiaritiesofanunderestimatedinfection |