Energy-Resolved Mass Spectrometry and Mid-Infrared Spectroscopy for Purity Assessment of a Synthetic Peptide Cyclised by Intramolecular Huisgen Click Chemistry

Energy-Resolved Mass Spectrometry and Mid-Infrared Spectroscopy for Purity Assessment of a Synthetic Peptide Cyclised by Intramolecular Huisgen Click Chemistry

Cyclic peptides have higher stability and better properties as therapeutic agents than their linear peptide analogues. Consequently, intramolecular click chemistry is becoming an increasingly popular method for the synthesis of cyclic peptides from their isomeric linear peptides. However, assessing...

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Bibliographic Details
Main Authors: Alicia Maroto, Ricard Boqué, Dany Jeanne Dit Fouque, Antony Memboeuf
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Methods and Protocols
Subjects:
peptide isomers
quantification
click chemistry
energy-resolved mass spectrometry
infrared microscopy
multivariate and univariate calibration
Online Access:https://www.mdpi.com/2409-9279/7/6/97
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